The Best- And Worst-Performing Biotech Stocks July 5 To July 12

These are the best and worst-performing medical and biotech stocks from July 5, 2013, to July 12, 2013. This screen includes biotechnology and medical companies traded on the New York Stock Exchange, the Nasdaq or the American Stock Exchange that had market capitalizations of more than $300 million as of a week ago. The data come from Interactive Data and Thomson Reuters Fundamentals via FactSet Research Systems. The Best Performers Recent 1-week 52-week Market price price value change change Ticker Company ($MIL) % % RNA Prosensa Holding N.V. 943.6 41.2 #N/A ALNY Alnylam Pharmaceuticals Inc. 3,111.0 32.3 302.6 ITMN InterMune Inc. 1,017.0 24.5 10.2 PCYC Pharmacyclics Inc. 7,865.2 24.2 98.3 EPZM Epizyme Inc. 993.3 22.0 #N/A TSRX Trius Therapeutics Inc. 473.5 19.4 67.9 ASTX Astex Pharmaceuticals Inc. 501.7 18.9 146.1 ACRX AcelRx Pharmaceuticals Inc. 455.4 18.9 256.6 VVUS VIVUS Inc. 1,479.8 18.7 -47.0 ALXN Alexion Pharmaceuticals Inc. 22,297.5 18.5 17.6 The Worst Performers Recent 1-week 52-week Market price price value change change Ticker Company ($MIL) % % MACK Merrimack Pharmaceuticals Inc. 488.1 -27.4 -29.4 ISRG Intuitive Surgical Inc. 17,230.7 -14.9 -19.7 GTXI GTx Inc. 365.4 -14.6 57.5 BABY Natus Medical Inc. 370.4 -14.6 -3.2 AMRN Amarin Corp. PLC ADS 791.7 -11.7 -64.1 MDXG MiMedx Group Inc. 592.5 -6.9 180.9 CLDX Celldex Therapeutics Inc. 1,644.1 -4.4 291.7 ALOG Analogic Corp. 874.5 -4.4 15.8 FLDM Fluidigm Corp. 418.7 -4.1 23.7 NXTM NxStage Medical Inc. 823.8 -4.0 -11.6 The Best-Performing Biotech Stocks Of The Past 52 Weeks Recent 1-week 52-week Market price price value change change Ticker Company ($MIL) % % SRPT Sarepta Therapeutics Inc 1,413.6 9.0 973.4 ACAD ACADIA Pharmaceuticals Inc. 1,463.8 2.5 944.6 AEGR Aegerion Pharmaceuticals Inc. 2,230.2 8.9 424.5 PBYI Puma Biotechnology Inc. 1,594.7 -0.3 394.3 ALNY Alnylam Pharmaceuticals Inc. 3,111.0 32.3 302.6 KERX Keryx Biopharmaceuticals Inc. 662.7 1.6 293.7 CLDX Celldex Therapeutics Inc. 1,644.1 -4.4 291.7 TEAR TearLab Corp. 343.6 7.2 260.5 ACRX AcelRx Pharmaceuticals Inc. 455.4 18.9 256.6 CLVS Clovis Oncology Inc. 2,208.7 -0.9 249.6 CYTK Cytokinetics Inc. 361.7 7.9 248.5

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